Description
What it is
Sermorelin, also written GRF (1-29) or GHRH(1-29), is the native N-terminal 29-residue fragment of human growth hormone releasing hormone. It is a linear, C-terminally amidated peptide with the formula C149H246N44O42S and a free-base mass of roughly 3358 g/mol (CAS 86168-78-7; acetate 114466-38-5). It is almost always supplied as a lyophilised acetate salt.
Research context
Sermorelin is characterised in the literature as a GHRH-receptor agonist and represents the unmodified parent sequence from which analogues such as modified GRF(1-29) are derived. Its defining chemical feature is methionine at position 27, which makes it the only molecule in this GHRH cluster whose formula contains sulfur, a clean identity fingerprint against its close lookalikes. AxYn lists it strictly as a reference molecule for in-vitro laboratory investigation.
331 studies indexed on PubMed (NIH) for Sermorelin as of August 2026. A measure of research volume only, not a claim of efficacy.
Handling and storage
Supplied as a lyophilised powder for reconstitution with bacteriostatic or sterile water as a research-handling step only. Store the sealed vial cold and protected from light. The stability watch-point unique to sermorelin is methionine-27 oxidation, so protect from light, heat and air and keep reconstituted material cold with minimal freeze-thaw.
Testing and quality
Every batch is third-party tested by HPLC and mass spectrometry, with the observed mass near 3358 g/mol and the sulfur signature used to distinguish sermorelin from modified GRF(1-29) and tesamorelin. A Certificate of Analysis (CoA) accompanies each batch. Supplied for laboratory research use only. Not for human or animal consumption.
Specification
Frequently asked questions
Research handling and related compounds
New to handling lyophilised material? See our reconstitution guide, the storage and shelf-life guide, and how to read a Certificate of Analysis.
Related research compounds in Growth Hormone Secretagogues: Tesamorelin, Ipamorelin, CJC-1295 (no-DAC).


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