Description
What it is
GHK-Cu is a copper-binding tripeptide, glycyl-L-histidyl-L-lysine (Gly-His-Lys) carrying a bound copper(II) ion, also catalogued under the INCI name Copper Tripeptide-1. The peptide holds the copper in a near-square-planar site formed by the N-terminal amine of glycine, the imidazole nitrogen of histidine and the deprotonated backbone amide nitrogen, giving a defined 1:1 peptide-to-copper complex rather than a loose salt. The free peptide has the molecular formula C14H24N6O4 (about 340.4 g/mol), while the copper complex is commonly written C14H22CuN6O4. It carries the CAS number 89030-95-5 for the complex.
Research context
GHK-Cu is studied as a model copper-delivery and matrix-signalling tripeptide in in-vitro fibroblast and tissue-remodelling research, and as a reference compound in copper-chelation and antioxidant assay work. It is supplied here purely as a laboratory reagent for such investigational use.
76 studies indexed on PubMed (NIH) for GHK-Cu as of August 2026. A measure of research volume only, not a claim of efficacy.
Handling and storage
Presented as a lyophilised powder. For research handling the powder is reconstituted with bacteriostatic water; store the lyophilised material cold and protected from light, and keep any reconstituted solution refrigerated and short-lived. The characteristic blue to violet colour is a useful stability cue, as fading toward green or brown can indicate copper release or oxidation.
Testing and quality
Supplied with a Certificate of Analysis. Specification covers stated copper content and 1:1 ratio, HPLC purity with chromatogram and mass spectrometry confirmation of the peptide. Supplied for laboratory research use only. Not for human or animal consumption.
Specification
Frequently asked questions
Research handling and related compounds
New to handling lyophilised material? See our reconstitution guide, the storage and shelf-life guide, and how to read a Certificate of Analysis.
Related research compounds in Skin & Cosmetic: MT-II.
Further reading: GHK-Cu copper peptide primer.




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