Description
What it is
KPV is the tripeptide Lys-Pro-Val, corresponding to residues 11 to 13 (the C-terminal fragment) of alpha-melanocyte-stimulating hormone (alpha-MSH). Its molecular formula is C16H30N4O4 with a free-base mass of about 342.4 g/mol (PubChem CID 125672, CAS 67727-97-3). With only three residues and no cysteine, it forms no disulphide bridges, and unlike the parent hormone it does not carry the sequence associated with pigmentation.
Research context
In the research literature KPV is described as an anti-inflammatory tripeptide that is taken up by the PepT1 di/tripeptide transporter and reported to act on NF-kB and IKK signalling, independent of the classic melanocortin receptors. The available evidence is drawn from cell and rodent models, with gut and skin inflammation the most studied contexts. This description covers the molecule for in-vitro laboratory investigation only and makes no claim of any effect in humans or animals.
114 studies indexed on PubMed (NIH) for KPV as of August 2026. A measure of research volume only, not a claim of efficacy.
Handling and storage
Supplied lyophilised, usually as the acetate salt, for reconstitution with bacteriostatic water as a research-handling step. Store the lyophilised powder cold and protected from light; reconstituted peptide is less stable and cold-chain dependent. Avoid repeated freeze-thaw cycles.
Testing and quality
Every batch is third-party tested. Because short peptides are easy to mis-synthesise, the Certificate of Analysis reports HPLC purity with chromatogram and mass-spectrometry identity (expected versus observed mass keyed to the Lys-Pro-Val sequence), along with the stated salt form.
Supplied for laboratory research use only. Not for human or animal consumption.
Specification
Frequently asked questions
Research handling and related compounds
New to handling lyophilised material? See our reconstitution guide, the storage and shelf-life guide, and how to read a Certificate of Analysis.
Related research compounds in Recovery & Repair: ARA-290, BPC-157, TB-500.



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